Cathie Wood’s ARK Investment Management made several portfolio changes on October 29, 2025, according to the firm’s daily trade report. The most substantial purchase involved DraftKings Inc, with ARK buying 97,783 shares across three funds.
DraftKings Inc., DKNG
The DraftKings purchase totaled $3,046,918 and was split between the ARKK, ARKW, and ARKF ETFs. The sports betting company’s stock has declined 18% year-to-date and dropped 11.1% over the past five trading sessions.
The recent drop in DraftKings shares came partly due to news about Polymarket’s plans to return to the U.S. market. The privately held company intends to focus on sports betting in the coming weeks, adding competition to the sector.
DraftKings recently acquired Railbird Technologies to enter prediction markets. This purchase represents the company’s latest strategic expansion effort.
ARK also invested heavily in genomics companies during Wednesday’s trading session. The firm purchased 1,028,318 shares of Pacific Biosciences through the ARKK fund for approximately $2,025,786.
Pacific Biosciences develops and manufactures DNA sequencing systems. The purchase continues ARK’s recent buying pattern for the genomics company over the past week.
ARK acquired 221,801 shares of 10X Genomics split between ARKK and ARKG funds. The purchase was valued at $2,958,825.
10X Genomics creates instruments, reagents, and software for analyzing individual cells. ARK has been consistently increasing its position in the company over recent days.
Both Pacific Biosciences and 10X Genomics are scheduled to release quarterly earnings next week. The timing of ARK’s purchases suggests possible anticipation of strong results.
On the sell side, ARK divested 3,633 shares of Shopify through its ARKF ETF. The sale totaled $650,161.
Shopify is set to report Q3 fiscal year 2025 earnings on November 4. ARK has been reducing its Shopify holdings as part of a broader selling trend.
The reduction in Shopify shares reflects ARK’s strategy to shift capital into sectors like artificial intelligence, genomics, and next-generation internet technologies. The firm has been moving away from traditional e-commerce investments.
ARK’s October 29 trades show a focus on companies in the genomics and biotech sectors. The firm also made a large bet on DraftKings during a period of stock price weakness.
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