Billionaire Stanley Druckenmiller Bets $517,000,000 on Single Asset, Increasing Exposure To Largest Holding

Billionaire Stanley Druckenmiller is increasing his asset management firm’s exposure to a bet on the future of American healthcare.

Druckenmiller’s Duquesne Family Office boosted its stake in Natera Inc. (NTRA) by 4.19% in the third quarter of 2025.

The firm now holds 3,214,532 shares, valued at $517.4 million.

The position accounts for 12.74% of the $4.06 billion portfolio, making it the largest holding.

The increase added 129,342 shares, as reported in the firm’s latest 13F-HR filing with the SEC for the quarter ended September 30, 2025.

Druckenmiller initially bought the stock when Natera traded sideways from late 2022 to early 2023.

He added shares during a subsequent rally, took profits in Q1 and Q2 2025, and then bought the dip last quarter.

Natera specializes in non-invasive cell-free DNA testing for oncology, women’s health, and organ health.

The company reported 34.66% year-over-year revenue growth in Q3 2025, exceeding analyst estimates. Its stock has surged over 500% since bottoming in October 2023.

A number of analysts project Natera’s earnings per share to turn positive in 2028, with double-digit revenue growth expected through the next decade.

 

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