MSFT vs AMGN Stock Comparison: Price, Growth & Valuation (2026)
Use MEXC Stock Compare for a detailed MSFT vs AMGN analysis. Compare MSFT and AMGN across price performance, growth, valuation, profitability and risk, based on market data and the latest reported financials.
MSFT vs AMGN Stock Comparison Summary
MSFT reported year-over-year revenue growth of 17.8%, compared with 9.1% for AMGN. Their P/E ratios are 27.8x and 25.1x, dividend yields are 0.71% and 2.41%, and 30-day volatility levels are 21.5% and 38.8%, respectively. These metrics highlight key differences in growth, valuation, dividend income and market risk. Overall neither stock has a clear lead based on the selected metrics.
Risk Disclaimer: MEXC Stock Compare provides information and comparisons on actual U.S.-listed stocks for reference only. Data may be delayed or inaccurate, does not constitute investment advice, and past performance does not guarantee future results.
MSFT vs AMGN Stock Return Comparison (1W)
Compare the cumulative total returns of Microsoft Corp. (MSFT) and Amgen Inc. (AMGN) over the selected 1W period. Data as of 2026-09-24 12:00:00.
MSFT vs AMGN Key Equity Metrics Comparison Summary
Microsoft Corp. (MSFT) has a market capitalization of $3.70T and operates in the Information Technology sector, with its main business classified under Systems Software. Its latest quarterly revenue changed +17.8% year over year.
Amgen Inc. (AMGN) has a market capitalization of $219.98B and operates in the Health Care sector, with its main business classified under Biotechnology. Its latest quarterly revenue changed +9.1% year over year.
MSFT vs AMGN Key Stock Indicators
| Comparison Metric | MSFT | AMGN | Comparison results |
Stock Price & Returns Latest delayed stock price with 1-day, 1-month and year-to-date returns. | $497.891D: -1.0%1M: -0.2%1Y: -2.4% | $406.901D: -0.4%1M: -8.0%1Y: +45.7% | AMGNWin |
Market Capitalization Total market value of the company's outstanding shares. | $3.70T | $219.98B | MSFTWin |
Sector & Industry The company's market sector and primary industry classification. | Information Technology / Systems Software | Health Care / Biotechnology | -- |
| Based on delayed market data, MSFT is trading at $497.89, compared with $406.90 for AMGN. Their market capitalizations are $3.70T and $219.98B, respectively. MSFT operates in the Information Technology sector, while AMGN belongs to Health Care. | |||
| MSFT vs AMGN Growth & Profitability | |||
Revenue Growth (YoY) Year-over-year change in revenue. | +17.8% | +9.1% | MSFTWin |
EPS Growth (YoY) Year-over-year change in earnings per share. | +31.7% | +31.7% | MSFTWin |
ROIC Return generated from invested capital. | 26.6% | 16.7% | MSFTWin |
Gross Margin / Operating Margin Profitability before and after operating expenses. | 67.9% / 46.8% | 69.5% / 30.0% | AMGNWin |
| On growth, MSFT posted revenue growth of +17.8% and TTM EPS growth of +31.7%. AMGN, by comparison, posted revenue growth of +9.1% and TTM EPS growth of +31.7%.On profitability, MSFT recorded a gross margin of 67.9%, an operating margin of 46.8%, and ROIC of 26.6%. For AMGN, the corresponding figures were 69.5%, 30.0%, and 16.7%.Overall, MSFT shows stronger overall growth and profitability. | |||
| MSFT vs AMGN Valuation & Balance Sheet | |||
Free Cash Flow Yield Free cash flow as a percentage of market capitalization. | 1.8% | 4.6% | AMGNWin |
Net Debt / EBITDA Net debt relative to EBITDA; a negative value indicates net cash. | 0.1x | 2.8x | MSFTWin |
Dividend Yield / Payout Ratio Dividend returns relative to share price and the share of earnings paid as dividends. | 0.71% / 19.5% | 2.41% / 60.4% | AMGNWin |
| AMGN offers a higher free cash flow yield, indicating a less demanding valuation. MSFT has the stronger balance sheet, while AMGN provides the higher dividend yield. Overall, the two stocks differ mainly in valuation, financial strength and dividend income. | |||
| MSFT vs AMGN Returns & Risk | |||
Total Return (Dividend-Adjusted) Cumulative return over 1, 5 and 10 years, including dividends. | 1Y: -2.4%5Y: +66.3%10Y: +775.0% | 1Y: +45.7%5Y: +90.5%10Y: +134.5% | MSFTWin |
30-Day Realized Volatility Annualized volatility based on the past 30 days of daily returns. | 21.5% | 38.8% | MSFTWin |
Beta (5Y vs S&P 500) Sensitivity to market movements; above 1 indicates greater market volatility. | 1.13 | 0.43 | AMGNWin |
| AMGN has delivered stronger long-term returns, but the risk indicators show mixed results. | |||
MSFT vs AMGN Valuation & Dividend Metrics
Review MSFT compared with AMGN across valuation, cash flow and dividend metrics, including P/E, forward P/E, free cash flow yield and dividend yield. These figures are provided for reference only and do not represent a fair-value estimate, price target or investment recommendation.
| Metric | MSFT | AMGN | Comparison results |
|---|---|---|---|
Market Cap | $3.70T | $219.98B | MSFTWin |
P/E (TTM) | 27.8x | 25.1x | AMGNWin |
P/S | 11.2x | 5.8x | AMGNWin |
EV/EBITDA | 18.8x | 16.3x | AMGNWin |
Dividend Yield | 0.71% | 2.41% | AMGNWin |
MSFT vs AMGN Profitability Over Time
Compare MSFT and AMGN across gross margin and operating margin trends over time to understand how each company's profitability has changed. Based on reported financial data only; not a forecast or investment advice.
| TTM | 3Y Avg | 5Y Avg | 10Y Avg | |
|---|---|---|---|---|
| MSFT | 68.4% | 68.9% | 68.8% | 67.3% |
| AMGN | 67.2% | 66.3% | 69.9% | 75.4% |
Technical & Fundamental Stock Analysis
RSI (14, daily)
MSFT 54.61 • AMGN 52.45
Measures short-term price momentum and helps identify possible overbought or oversold conditions.
50/200-DMA Position
MSFT 50D Above / 200D Above • AMGN 50D Above / 200D Above
Shows whether the stock is trading above or below its medium- and long-term trend lines.
R&D % of Revenue
MSFT 10.7% • AMGN 20.0%
Shows how much of revenue is invested in research and development.
Share Count Trend (3Y)
MSFT Stable • AMGN Stable
Shows whether the company's share count has increased or decreased over the past three years.
Company Profiles
Microsoft Corp.
Systems Software
Microsoft develops and licenses consumer and enterprise software. It is known for its Windows operating systems and Office productivity suite. The company is organized into three equally sized broad segments: productivity and business processes (legacy Microsoft Office, cloud-based Office 365, Exchange, SharePoint, Skype, LinkedIn, Dynamics), intelligence cloud (infrastructure- and platform-as-a-service offerings Azure, Windows Server OS, SQL Server), and more personal computing (Windows Client, Xbox, Bing search, display advertising, and Surface laptops, tablets, and desktops).
Amgen Inc.
Biotechnology
Amgen is a leader in biotechnology-based human therapeutics. Flagship drugs include red blood cell boosters Epogen and Aranesp, immune system boosters Neupogen and Neulasta, and Enbrel and Otezla for inflammatory diseases. Amgen introduced its first cancer therapeutic, Vectibix, in 2006 and markets bone-strengthening drugs Prolia/Xgeva (approved 2010) and Evenity (2019). The acquisition of Onyx Pharmaceuticals bolstered the firm's therapeutic oncology portfolio with Kyprolis, which has been further strengthened with the launch of new drugs in blood cancers (Blincyto) and solid tumors (Imdelltra). The 2023 Horizon acquisition brought several rare-disease drugs, including thyroid eye disease drug Tepezza. Amgen also has a growing biosimilar portfolio.
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Everything You Need to Know About MSFT vs AMGN Stocks
What is MEXC Stock Compare?
MEXC Stock Compare is a side-by-side US stock comparison tool. It helps users compare two companies across stock price performance, market cap, valuation, growth, profitability, balance-sheet strength, dividends and risk. The results are provided for research purposes only and do not constitute investment advice.
Which metrics should I use to evaluate a company's growth?
Start with revenue growth to see how quickly the business is expanding, then review EPS growth to determine whether that growth is translating into higher earnings per share. Gross margin, operating margin and ROIC help assess the quality of that growth by showing profitability and capital efficiency. A company with fast revenue growth but declining margins may be expanding without improving its earnings quality.
How do MSFT and AMGN compare in growth and profitability?
In the latest reported period, MSFT recorded revenue growth of +17.8% and TTM EPS growth of +31.7%, compared with +9.1% and +31.7% for AMGN. MSFT leads on both growth and profitability. This comparison is based on reported financial metrics and does not predict future performance.
What is the difference between P/E (TTM) and Forward P/E?
P/E (TTM) compares the current share price with actual earnings reported over the past 12 months. Forward P/E uses estimated earnings for the next 12 months, so it reflects market expectations but depends on forecasts that may change. Both ratios should be considered alongside growth, profitability and industry peers.
How do the risk profiles of MSFT and AMGN compare?
MSFT has a 30-day realized volatility of 21.5% and a five-year Beta of 1.13, compared with 38.8% and 0.43 for AMGN. The risk indicators show mixed results. These indicators describe historical price movements and market sensitivity, but they do not cover every source of investment risk.
What do dividend yield and payout ratio indicate?
Dividend yield shows the annual dividend relative to the current share price, while the payout ratio shows how much of a company's earnings is distributed as dividends. A higher yield may provide more income, but it can also rise because the share price has fallen. Dividend sustainability should therefore be considered together with earnings, cash flow and the payout ratio.
How should I compare a high-growth stock with a lower-valued stock?
A high-growth stock may trade at a higher valuation if investors expect its revenue and earnings to continue expanding. A lower-valued stock may offer a more conservative entry point, but the lower valuation could also reflect slower growth or higher business risk. Growth, valuation, profitability, cash flow and risk should therefore be considered together.
Which is the better stock, MSFT or AMGN?
There is no single answer for every investor. Growth-focused investors may place greater weight on revenue growth, EPS growth and ROIC, while income-focused investors may prioritize dividend yield and payout sustainability. Investors with lower risk tolerance may focus more on volatility, Beta and balance-sheet strength. MEXC Stock Compare presents the relevant metrics but does not provide a buy or sell recommendation.
Can I trade MSFT and AMGN as RealStocks on MEXC?
Eligible users can trade MSFT and AMGN as real US stocks through MEXC RealStocks if both stocks are currently supported. Users must first open and verify a RealStocks account with MEXC's partner licensed broker. RealStocks represents ownership of actual shares rather than tokenized stock exposure. Availability may vary by stock and region, so users should check the corresponding RealStocks trading page before placing an order.
Disclaimer
The stock prices, financial metrics, comparison results and related information displayed on this page are sourced from third-party providers and are provided for informational and educational purposes only. Data may be delayed, incomplete or inaccurate, and MEXC does not guarantee its accuracy, completeness or timeliness. The comparisons and automated summaries do not constitute financial, investment, legal or tax advice, nor a recommendation to buy, sell or hold any security or financial product. Past performance is not indicative of future results. Users should independently verify the information and assess their own objectives, financial circumstances and risk tolerance before making any decision. Where MEXC stock futures or other derivative products are referenced, such products do not represent ownership of the underlying shares and may involve leverage and a substantial risk of loss. Product availability is subject to applicable laws and regional restrictions.