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Upstream Bio, Inc. (UPB)

NASDAQ

$5.34

$-0.15

(-2.68%)

Pre-Market

Upstream Bio, Inc. (UPB) Live Price Chart

Last updated: ⁦2026-09-16 10:31:20⁩. Prices reflect the latest pre-market trading data. Stock price data is sourced from Massive.

Summary

Upstream Bio, Inc. (UPB) operates in the PHARMACEUTICAL PREPARATIONS sector and is listed on NASDAQ. The stock is currently priced at $5.34, with a market capitalisation of $318.22M and a P/E ratio of --. Over the past 52 weeks, its price has ranged from $5.34 to $33.68. This page covers its latest market performance, valuation, price trends and company information.

Key Market Data

Market Cap	$318.22M
Open	$5.49
Day's High	$33.68
Day's Low	$5.14
Previous Close	$5.48
Volume	21.00
Average Volume	599.49K
P/E Ratio	--
52-Week High	$33.68
52-Week Low	$5.34
Dividend Yield	--
Earnings Date	--

Upstream Bio, Inc. (UPB) Pre-Market Stock Price

Upstream Bio, Inc. (UPB) is trading at $5.34 in pre-market trading as of 2026-09-16 09:58:00, down 2.59% ($0.14) from the previous close of $5.48

Pre-market trading shows how investors are pricing UPB before the regular session opens. The current pre-market price is below the previous close, indicating cautious early trading sentiment.

Upstream Bio, Inc. (UPB) 7-Day Stock Price Change

Over the past seven days, Upstream Bio, Inc. (UPB) moved from $6.01 to $5.34, representing a decline of 11.18% ($0.67).

The stock traded between $5.34 and $6.23 during the period. The latest price is near the lower end of the 7-day range, indicating strong downward.

The average daily volume was 613.96 thousand shares, down versus the previous seven-day period, indicating lower trading activity.

UPB 52-Week Price Position

Position in Range: 0.0%

52W Low$5.34

52W High$33.68

UPB is currently trading at $5.34, placing it 0.0% of the way from its 52-week low of $5.34 to its 52-week high of $33.68. This percentage reflects the stock's relative position within its 52-week trading range, not its valuation or future performance.

What is Upstream Bio, Inc. (UPB)?

Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).

Upstream Bio, Inc. Information

Industry	PHARMACEUTICAL PREPARATIONS
Employees	75
Exchange	NASDAQ
Company Website	https://www.upstreambio.com

How to Buy Upstream Bio, Inc. (UPB) Stock on MEXC

Eligible investors can buy real shares of Upstream Bio, Inc. (UPB) through MEXC RealStocks. Follow these three steps to open a RealStocks account, transfer USDT, and place a US stock order.

Step 1: Open and Verify Your RealStocks Account

Log in to the MEXC App, go to Trade → RealStocks, and select Open Account. Complete the required account-opening and identity verification process with MEXC's partner licenced broker.

Step 2: Transfer USDT to Your RealStocks Account

Go to Wallets → RealStocks and transfer USDT from your Spot Account to your RealStocks Account. RealStocks are quoted in USD, while account funding can be completed using USDT.

Step 3: Search for UPB and Place Your Order

Open the RealStocks trading page and search for UPB. Select a market or limit order, enter the price and quantity as required, review the order details, and submit your order. Once filled, the corresponding real shares will be held in your RealStocks Account.

Frequently Asked Questions (FAQ)

1.What is Upstream Bio, Inc. (UPB) stock price today?

Upstream Bio, Inc. (UPB) is currently trading at $ 5.34, down 2.59% ($0.14) from the previous close of $ 5.48. Intraday prices update in real time during regular trading hours.

2.Is UPB stock going up or down today?

As of 2026-09-16 09:58:00, UPB is trading at $ 5.34, down 2.59% ($0.14) from its previous close of $ 5.48. The stock has traded between $ 5.14 and $ 33.68 during today’s regular session. Past price movements do not guarantee future results.

3.What is UPB pre-market price?

As of 2026-09-16 09:58:00, UPB is trading at $ 5.34 in pre-market trading, down 2.59% ($0.14) from the previous close of $ 5.48. Pre-market prices reflect trading activity before the regular session opens and may experience lower liquidity and higher volatility.

4.What is UPB after-hours price?

As of 2026-09-16 09:58:00, UPB is trading at $ 5.49 in after-hours trading, up 0.09% ($0.00) from the regular-session close of $ 5.48. After-hours prices may differ from the regular session’s opening price due to lower liquidity and wider bid-ask spreads.

5.Is UPB stock trading now?

UPB trades on the NASDAQ exchange during regular hours, Monday through Friday, 9:30 AM to 4:00 PM ET, excluding public holidays. Pre-market and after-hours trading are also available through select brokers outside these hours.

6.Where does UPB sit relative to its 52-week high and low?

Over the past 52 weeks, UPB has traded between a low of $ 5.34 and a high of $ 33.68. At $ 5.34, the stock is positioned 0.0% of the way from its 52-week low to its 52-week high, providing context for its current price within the one-year trading range.

7.What sector is Upstream Bio, Inc. in?

Upstream Bio, Inc. (UPB) operates in the PHARMACEUTICAL PREPARATIONS sector. Sector classification helps investors compare it with companies exposed to similar market trends and competitive conditions.

8.What is Upstream Bio, Inc.'s market capitalisation and where is it listed?

Upstream Bio, Inc. is listed on the NASDAQ exchange with a market capitalisation of $ 318.22M. Market cap reflects the total market value of all outstanding shares and is commonly used to classify stocks by size.

9.How is UPB valued in terms of P/E ratio and EPS?

UPB trades at a P/E ratio of --, based on trailing-twelve-month EPS of $ -2.86. P/E ratio compares the stock price to earnings per share and is a common starting point for assessing valuation relative to peers.

10.Does Upstream Bio, Inc. pay a dividend?

Upstream Bio, Inc. pays an indicated annual cash dividend of $ 0.00 per share, with a current dividend yield of 0.00% based on the latest share price. Dividend policies are subject to change at the board's discretion.