MRNA vs MSFT Stock Comparison: Price, Growth & Valuation (2026)
Use MEXC Stock Compare for a detailed MRNA vs MSFT analysis. Compare MRNA and MSFT across price performance, growth, valuation, profitability and risk, based on market data and the latest reported financials.
MRNA vs MSFT Stock Comparison Summary
MRNA reported year-over-year revenue growth of -27.6%, compared with 17.8% for MSFT. Their P/E ratios are -- and 28.7x, dividend yields are 0.00% and 0.69%, and 30-day volatility levels are 305.6% and 23.8%, respectively. These metrics highlight key differences in growth, valuation, dividend income and market risk. Overall MSFT leads across more of the selected comparison metrics.
Risk Disclaimer: MEXC Stock Compare provides information and comparisons on actual U.S.-listed stocks for reference only. Data may be delayed or inaccurate, does not constitute investment advice, and past performance does not guarantee future results.
MRNA vs MSFT Stock Return Comparison (1W)
Compare the cumulative total returns of Moderna, Inc. (MRNA) and Microsoft Corp. (MSFT) over the selected 1W period. Data as of 2026-09-25 12:00:00.
MRNA vs MSFT Key Equity Metrics Comparison Summary
Moderna, Inc. (MRNA) has a market capitalization of $79.39B and operates in the Health Care sector, with its main business classified under Biotechnology. Its latest quarterly revenue changed -27.6% year over year.
Microsoft Corp. (MSFT) has a market capitalization of $3.83T and operates in the Information Technology sector, with its main business classified under Systems Software. Its latest quarterly revenue changed +17.8% year over year.
MRNA vs MSFT Key Stock Indicators
| Comparison Metric | MRNA | MSFT | Comparison results |
Stock Price & Returns Latest delayed stock price with 1-day, 1-month and year-to-date returns. | $198.861D: +2.1%1M: +41.7%1Y: +685.2% | $516.111D: +3.7%1M: +1.7%1Y: +0.3% | MRNAWin |
Market Capitalization Total market value of the company's outstanding shares. | $79.39B | $3.83T | MSFTWin |
Sector & Industry The company's market sector and primary industry classification. | Health Care / Biotechnology | Information Technology / Systems Software | -- |
| Based on delayed market data, MRNA is trading at $198.86, compared with $516.11 for MSFT. Their market capitalizations are $79.39B and $3.83T, respectively. MRNA operates in the Health Care sector, while MSFT belongs to Information Technology. | |||
| MRNA vs MSFT Growth & Profitability | |||
Revenue Growth (YoY) Year-over-year change in revenue. | -27.6% | +17.8% | MSFTWin |
EPS Growth (YoY) Year-over-year change in earnings per share. | -4.6% | +31.7% | MSFTWin |
ROIC Return generated from invested capital. | -39.4% | 26.6% | MSFTWin |
Gross Margin / Operating Margin Profitability before and after operating expenses. | 23.4% / -149.0% | 67.9% / 46.8% | MSFTWin |
| On growth, MRNA posted revenue growth of -27.6% and TTM EPS growth of -4.6%. MSFT, by comparison, posted revenue growth of +17.8% and TTM EPS growth of +31.7%.On profitability, MRNA recorded a gross margin of 23.4%, an operating margin of -149.0%, and ROIC of -39.4%. For MSFT, the corresponding figures were 67.9%, 46.8%, and 26.6%.Overall, MSFT shows stronger overall growth and profitability. | |||
| MRNA vs MSFT Valuation & Balance Sheet | |||
Free Cash Flow Yield Free cash flow as a percentage of market capitalization. | -1.6% | 1.7% | MSFTWin |
Net Debt / EBITDA Net debt relative to EBITDA; a negative value indicates net cash. | 0.6x | 0.1x | MSFTWin |
Dividend Yield / Payout Ratio Dividend returns relative to share price and the share of earnings paid as dividends. | 0.00% / 0.0% | 0.69% / 19.8% | MSFTWin |
| MSFT offers a higher free cash flow yield, indicating a less demanding valuation. MSFT has the stronger balance sheet, while MSFT provides the higher dividend yield. Overall, the two stocks differ mainly in valuation, financial strength and dividend income. | |||
| MRNA vs MSFT Returns & Risk | |||
Total Return (Dividend-Adjusted) Cumulative return over 1, 5 and 10 years, including dividends. | 1Y: +685.2%5Y: -51.4%10Y: +969.2% | 1Y: +0.3%5Y: +75.5%10Y: +790.7% | MRNAWin |
30-Day Realized Volatility Annualized volatility based on the past 30 days of daily returns. | 305.6% | 23.8% | MSFTWin |
Beta (5Y vs S&P 500) Sensitivity to market movements; above 1 indicates greater market volatility. | 1.36 | 1.13 | MSFTWin |
| MRNA has delivered stronger long-term returns, but MRNA also shows higher recent volatility and market sensitivity. | |||
MRNA vs MSFT Valuation & Dividend Metrics
Review MRNA compared with MSFT across valuation, cash flow and dividend metrics, including P/E, forward P/E, free cash flow yield and dividend yield. These figures are provided for reference only and do not represent a fair-value estimate, price target or investment recommendation.
| Metric | MRNA | MSFT | Comparison results |
|---|---|---|---|
Market Cap | $79.39B | $3.83T | MSFTWin |
P/E (TTM) | -- | 28.7x | -- |
P/S | 35.6x | 11.6x | MSFTWin |
EV/EBITDA | -25.4x | 19.4x | MRNAWin |
Dividend Yield | 0.00% | 0.69% | MSFTWin |
MRNA vs MSFT Profitability Over Time
Compare MRNA and MSFT across gross margin and operating margin trends over time to understand how each company's profitability has changed. Based on reported financial data only; not a forecast or investment advice.
| TTM | 3Y Avg | 5Y Avg | 10Y Avg | |
|---|---|---|---|---|
| MRNA | 55.3% | 47.2% | 59.9% | 74.8% |
| MSFT | 68.4% | 68.9% | 68.8% | 67.3% |
Technical & Fundamental Stock Analysis
RSI (14, daily)
MRNA 76.09 • MSFT 63.39
Measures short-term price momentum and helps identify possible overbought or oversold conditions.
50/200-DMA Position
MRNA 50D Above / 200D Above • MSFT 50D Above / 200D Above
Shows whether the stock is trading above or below its medium- and long-term trend lines.
R&D % of Revenue
MRNA 129.1% • MSFT 10.7%
Shows how much of revenue is invested in research and development.
Share Count Trend (3Y)
MRNA Increased • MSFT Stable
Shows whether the company's share count has increased or decreased over the past three years.
Company Profiles
Moderna, Inc.
Biotechnology
Moderna is a commercial-stage biotech that was founded in 2010 and had its initial public offering in 2018. The firm's mRNA technology was rapidly validated with its covid vaccine, which was authorized in the United States in December 2020. Moderna had 25 mRNA development candidates in clinical studies as of March 2026. Programs span a wide range of therapeutic areas, including infectious disease, oncology, cardiovascular disease, and rare genetic diseases.
Microsoft Corp.
Systems Software
Microsoft develops and licenses consumer and enterprise software. It is known for its Windows operating systems and Office productivity suite. The company is organized into three equally sized broad segments: productivity and business processes (legacy Microsoft Office, cloud-based Office 365, Exchange, SharePoint, Skype, LinkedIn, Dynamics), intelligence cloud (infrastructure- and platform-as-a-service offerings Azure, Windows Server OS, SQL Server), and more personal computing (Windows Client, Xbox, Bing search, display advertising, and Surface laptops, tablets, and desktops).
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Everything You Need to Know About MRNA vs MSFT Stocks
What is MEXC Stock Compare?
MEXC Stock Compare is a side-by-side US stock comparison tool. It helps users compare two companies across stock price performance, market cap, valuation, growth, profitability, balance-sheet strength, dividends and risk. The results are provided for research purposes only and do not constitute investment advice.
Which metrics should I use to evaluate a company's growth?
Start with revenue growth to see how quickly the business is expanding, then review EPS growth to determine whether that growth is translating into higher earnings per share. Gross margin, operating margin and ROIC help assess the quality of that growth by showing profitability and capital efficiency. A company with fast revenue growth but declining margins may be expanding without improving its earnings quality.
How do MRNA and MSFT compare in growth and profitability?
In the latest reported period, MRNA recorded revenue growth of -27.6% and TTM EPS growth of -4.6%, compared with +17.8% and +31.7% for MSFT. MSFT leads on both growth and profitability. This comparison is based on reported financial metrics and does not predict future performance.
What is the difference between P/E (TTM) and Forward P/E?
P/E (TTM) compares the current share price with actual earnings reported over the past 12 months. Forward P/E uses estimated earnings for the next 12 months, so it reflects market expectations but depends on forecasts that may change. Both ratios should be considered alongside growth, profitability and industry peers.
How do the risk profiles of MRNA and MSFT compare?
MRNA has a 30-day realized volatility of 305.6% and a five-year Beta of 1.36, compared with 23.8% and 1.13 for MSFT. MRNA shows higher historical volatility and market sensitivity. These indicators describe historical price movements and market sensitivity, but they do not cover every source of investment risk.
What do dividend yield and payout ratio indicate?
Dividend yield shows the annual dividend relative to the current share price, while the payout ratio shows how much of a company's earnings is distributed as dividends. A higher yield may provide more income, but it can also rise because the share price has fallen. Dividend sustainability should therefore be considered together with earnings, cash flow and the payout ratio.
How should I compare a high-growth stock with a lower-valued stock?
A high-growth stock may trade at a higher valuation if investors expect its revenue and earnings to continue expanding. A lower-valued stock may offer a more conservative entry point, but the lower valuation could also reflect slower growth or higher business risk. Growth, valuation, profitability, cash flow and risk should therefore be considered together.
Which is the better stock, MRNA or MSFT?
There is no single answer for every investor. Growth-focused investors may place greater weight on revenue growth, EPS growth and ROIC, while income-focused investors may prioritize dividend yield and payout sustainability. Investors with lower risk tolerance may focus more on volatility, Beta and balance-sheet strength. MEXC Stock Compare presents the relevant metrics but does not provide a buy or sell recommendation.
Can I trade MRNA and MSFT as RealStocks on MEXC?
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Disclaimer
The stock prices, financial metrics, comparison results and related information displayed on this page are sourced from third-party providers and are provided for informational and educational purposes only. Data may be delayed, incomplete or inaccurate, and MEXC does not guarantee its accuracy, completeness or timeliness. The comparisons and automated summaries do not constitute financial, investment, legal or tax advice, nor a recommendation to buy, sell or hold any security or financial product. Past performance is not indicative of future results. Users should independently verify the information and assess their own objectives, financial circumstances and risk tolerance before making any decision. Where MEXC stock futures or other derivative products are referenced, such products do not represent ownership of the underlying shares and may involve leverage and a substantial risk of loss. Product availability is subject to applicable laws and regional restrictions.