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52-Week Top Losing U.S. stocks

Track U.S. stocks with the largest price declines over the past 52 weeks on MEXC. Stocks are ranked by 52-week percentage change from lowest to highest.

52-Week Top Losing U.S. stocks

Market Overview

U.S. stocks are mixed today. The Dow Jones is ⁦+0.01%⁩, the S&P 500 is ⁦+0.53%⁩, and the Nasdaq Composite is ⁦+1.11%⁩. Across individual stocks, 2,499 are advancing while 2,618 are declining, suggesting a mixed market tone.

Dow Jones
52,364.27
Change
+2.69+0.01%
S&P 500
7,717.4
Change
+40.63+0.53%
Nasdaq Composite
26,459.118
Change
+289.737+1.11%
24H Gainers
2,499
24H Losers
2,618

52 Week Losers

#Stock52 Week Range
4951Septerna, Inc.SEPN$44.14+6.62%185.53K$2.06B$17.55 - $51.100.00%
4952Halozyme Therapeutics, Inc.HALO$128.52+0.39%1.07M$14.59B$61.23 - $128.910.00%
4953Targa Resources Corp.TRGP$302.53-0.74%758.71K$64.87B$150.00 - $307.940.01%
4954Target Hospitality Corp.TH$14.23+1.14%1.01M$1.42B$5.97 - $21.760.00%
4955Globalstar, Inc.GSAT$83.88+1.19%2.06M$10.87B$41.06 - $84.850.00%
4956BBB Foods Inc.TBBB$57.37-1.68%651.33K$4.47B$25.84 - $59.600.00%
4957Cogent Biosciences, Inc.COGT$32.02+3.61%1.40M$5.56B$13.78 - $43.730.00%
4958PHILLIPS 66PSX$268.25-7.03%2.51M$107.04B$127.16 - $299.390.02%
4959CMB.TECH NVCMBT$18.20-0.82%468.99K$5.36B$9.04 - $21.190.00%
4960BlackBerry LimitedBB$9.54+3.59%10.12M$5.60B$3.12 - $13.590.00%
4961Amylyx Pharmaceuticals, Inc.AMLX$28.30+4.50%901.63K$3.15B$10.83 - $41.140.00%
4962Quantum CorporationQMCO$20.24+8.35%1.00M$797.58M$4.19 - $35.650.00%
4963Liquidia CorporationLQDA$45.45+3.86%2.70M$4.07B$22.05 - $93.610.00%
4964The Manitowoc Company, Inc.MTW$22.52+0.85%198.02K$812.19M$9.93 - $24.000.00%
4965Caesarstone Ltd.CSTE$2.44+2.13%50.07K$84.40M$0.56 - $3.840.00%
4966Keysight Technologies, Inc.KEYS$336.11+3.09%1.11M$57.22B$165.06 - $389.930.00%
4967Neogen Corp.NEOG$12.46+2.01%2.46M$2.72B$5.37 - $14.260.00%
4968JFrog Ltd.FROG$100.47+0.81%1.12M$12.39B$34.05 - $105.760.00%
4969Bloom Energy CorporationBE$218.49+7.64%14.58M$64.60B$75.70 - $351.280.00%
4970BW LPG LimitedBWLP$25.50-2.11%180.40K$3.88B$11.72 - $26.710.00%
4971Orion Energy Systems, Inc.OESX$20.20+2.96%15.89K$82.61M$8.35 - $31.650.00%
4972Enlight Renewable Energy Ltd.ENLT$73.21+5.42%170.35K$9.57B$32.87 - $108.650.00%
4973CrowdStrike Holdings, Inc.CRWD$268.02+2.35%5.45M$275.02B$85.68 - $286.990.00%
4974Permian Resources CorporationPR$25.46-1.20%6.32M$18.97B$12.06 - $25.960.02%
4975MindForge Inc.MF$8.54-20.14%74.31K$19.96M$3.80 - $22.560.00%
4976Enliven Therapeutics, Inc.ELVN$43.69+5.35%1.32M$3.20B$14.79 - $62.320.00%
4977SharkNinja, Inc.SN$197.65-0.55%900.68K$27.84B$83.12 - $202.510.00%
4978Semtech Corp.SMTC$144.42+5.59%1.92M$13.48B$60.28 - $201.990.00%
4979Midland States Bancorp, Inc.MSBI$34.23+0.74%105.20K$710.37M$14.24 - $35.100.05%
4980Kforce Inc.KFRC$56.95-2.67%521.08K$1.02B$24.49 - $61.680.03%
4981Friedman Industries Inc.FRD$42.98+3.43%22.98K$309.98M$16.55 - $48.770.00%
4982Digi International Inc.DGII$78.90+3.45%179.31K$2.99B$34.41 - $86.840.00%
4983Teva Pharmaceutical Industries LimitedTEVA$40.41+1.10%5.59M$45.96B$19.00 - $42.020.00%
4984Funko, Inc.FNKO$6.53-2.40%686.93K$364.46M$2.72 - $7.350.00%
4985Applied Optoelectronics, Inc.AAOI$76.92+6.05%8.40M$6.51B$18.50 - $233.670.00%
4986ZIM Integrated Shipping Services Ltd.ZIM$29.72+0.20%310.78K$3.59B$13.94 - $30.980.00%
4987Centene CorporationCNC$68.68+1.43%10.30M$33.93B$31.63 - $72.500.00%
4988Everpure, Inc.P$138.84+5.83%2.63M$46.27B$64.80 - $157.570.00%
4989PUMA BIOTECHNOLOGY INC.PBYI$10.93+0.74%183.29K$564.21M$4.58 - $11.500.00%
4990HireQuest, Inc.HQI$17.20+0.15%12.83K$239.01M$7.38 - $20.840.01%
4991HF Sinclair CorporationDINO$114.12-10.63%2.84M$20.29B$45.71 - $129.370.02%
4992Everforth, Inc.EFOR$39.56-5.33%724.13K$1.62B$16.90 - $43.740.00%
4993Lulu's Fashion Lounge Holdings, Inc.LVLU$10.93+4.13%14.06K$31.40M$4.37 - $32.320.00%
4994Mistras Group Inc.MG$20.44-3.72%614.42K$650.92M$9.45 - $21.920.00%
4995GigaCloud Technology Inc.GCT$59.69+0.45%245.65K$1.72B$25.39 - $60.960.00%
4996Amneal Pharmaceuticals, Inc.AMRX$21.44+2.00%1.28M$6.85B$9.99 - $21.520.00%
4997Harvard Bioscience Inc.HBIO$8.41+1.33%5.27K$38.28M$3.95 - $9.400.00%
4998The Marcus CorporationMCS$28.27+1.40%69.17K$674.05M$12.88 - $32.420.01%
4999Xencor, Inc.XNCR$29.98+2.72%1.57M$2.23B$10.38 - $33.600.00%
5000Turn Therapeutics Inc.TTRX$10.47-1.84%91.76K$312.18M$2.57 - $16.450.00%

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Frequently Asked Questions (FAQ)

What are 52-week top losing U.S. stocks?
These are U.S. stocks that have recorded some of the largest price declines over the past 52 weeks.
How is the 52-week decline measured?
It compares the latest available stock price with its price around 52 weeks earlier and calculates the percentage change.
Which stock has fallen the most over 52 weeks?
Septerna, Inc. (SEPN) currently shows a 52-week decline of 95.12% as of 2026-10-27 21:50 UTC.
Why track 52-week stock losers?
The ranking helps identify stocks facing prolonged price weakness and provides a starting point for further company and valuation research.
Is a 52-week loser automatically a value stock?
No. A lower stock price does not necessarily mean a company is undervalued, so valuation and fundamental data should be reviewed separately.
How is this different from Top Losers?
52-Week Losers measures longer-term performance, while Top Losers focuses on shorter-term market declines.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.